A Multi-Enzyme Nanocascade to Target Disease-Relevant Metabolites

By sjmartinez • November 6, 2024

Cao Z, Ren J, Yang A, Wang Z, Love M, Chen W, Yuan X, Guo X, Chen I, Lu Y, Wen J. A Multi-Enzyme Nanocascade to Target Disease-Relevant Metabolites. Small. 2024 Nov 5:e2408481. doi: 10.1002/smll.202408481. Epub ahead of print. PMID: 39498716.

Tags: cancer starvation therapy, enzyme delivery, Hematology/Oncology, metabolic reprogramming, protein nanoparticles, Publications

Blocking Deoxycytidine Kinase in Activated Lymphocytes Depletes Deoxycytidine Triphosphate Pools and Alters Cell Cycle Kinetics to Yield Less Disease in a Mouse Multiple Sclerosis Model

Salas JR, Ryan KM, Trias AO, Chen BY, Guemes M, Galic Z, Schultz KA, Clark PM. Blocking Deoxycytidine Kinase in Activated Lymphocytes Depletes Deoxycytidine Triphosphate[...]

Targeting ketone body metabolism in mitigating gemcitabine resistance

Rohena-Rivera K, You S, Kim M, Billet S, Ten Hoeve J, Gonzales G, Huang C, Heard A, Chan KS, Bhowmick NA. Targeting ketone body metabolism[...]

Olutasidenib demonstrates significant clinical activity in mutated IDH1 acute myeloid leukaemia arising from a prior myeloproliferative neoplasm

De Botton S, Récher C, Cortes J, Curti A, Fenaux P, Peterlin P, Pigneux A, Yee K, Wei A, Mims A, Schiller G, Chao MM,[...]