A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer’s disease

By sjmartinez • September 6, 2024

Sakimura K, Kawai T, Nashida R, Ishida Y, Harada K, Suzuki T, Okuma C, Cole GM. A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer's disease. Alzheimers Res Ther. 2024 Sep 5;16(1):197. doi: 10.1186/s13195-024-01552-2. PMID: 39238036.

Tags: 5xFAD, Aerobic glycolysis, Alzheimer’s disease, Geriatrics, Glucose metabolism, GRECC, PDH, PDHK, Publications, Pyruvate dehydrogenase, Pyruvate dehydrogenase kinase, Veterans Administration

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