Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response

By sjmartinez • September 3, 2024

An J, Kurilov R, Peccerella T, Bergmann F, Edderkaoui M, Lim A, Zhou X, Pfütze K, Schulz A, Wolf S, Hu K, Springfeld C, Mughal SS, Zezlina L, Fortunato F, Beyer G, Mayerle J, Roth S, Hulkkonen J, Merz D, Ei S, Mehrabi A, Loos M, Al-Saeedi M, Michalski CW, Büchler MW, Hackert T, Brors B, Pandol SJ, Bailey P, Neoptolemos JP. Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response. Transl Oncol. 2024 Aug 31;49:102109. doi: 10.1016/j.tranon.2024.102109. Epub ahead of print. PMID: 39217851.

Tags: apoptosis, Autophagy, Cedars Sinai DoM, Digestive Diseases, GSK3-β, Histone deacetylases, Molecular subtypes, pancreatic cancer, Publications

Specific targeting of cancer cell mitochondria with a malaria drug improves pancreatic cancer outcome

Ou Y, Lim A, Wang R, Mir N, Calsavara VF, Wang Q, Zhang Y, Pandol SJ, Edderkaoui M. Specific targeting of cancer cell mitochondria with[...]

Beyond the field of view: Radiomics and artificial intelligence for organ-specific and systemic disease prediction from localized medical imaging

Wang L, Shi Y, Deng Z, Wang Y, Rigo De Righi D, Javed S, Qureshi TA, Yang JD, Xie Y, Pandol SJ, Li D. Beyond[...]

Examining the Interchangeability of Two Different Patient-Reported Global Assessment Measures in an Observational Axial Spondyloarthritis Cohort

Vershel C, Kim S, Gensler LS, Brown MA, Weisman MH, Ishimori ML, Ward M, Reveille JD, Hwang MC. Examining the Interchangeability of Two Different Patient-Reported[...]