Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response

By sjmartinez • September 3, 2024

An J, Kurilov R, Peccerella T, Bergmann F, Edderkaoui M, Lim A, Zhou X, Pfütze K, Schulz A, Wolf S, Hu K, Springfeld C, Mughal SS, Zezlina L, Fortunato F, Beyer G, Mayerle J, Roth S, Hulkkonen J, Merz D, Ei S, Mehrabi A, Loos M, Al-Saeedi M, Michalski CW, Büchler MW, Hackert T, Brors B, Pandol SJ, Bailey P, Neoptolemos JP. Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response. Transl Oncol. 2024 Aug 31;49:102109. doi: 10.1016/j.tranon.2024.102109. Epub ahead of print. PMID: 39217851.

Tags: apoptosis, Autophagy, Cedars Sinai DoM, Digestive Diseases, GSK3-β, Histone deacetylases, Molecular subtypes, pancreatic cancer, Publications

Related Posts

Activity of Brigatinib in Patients With Crizotinib-Resistant ALK-positive Non-Small-Cell Lung Cancer According to ALK Fusion and Mutation Status

Bazhenova L, Hodgson JG, Camidge DR, Langer CJ, Huber RM, Kim DW, Reckamp KL, Ahn MJ, Tan DSW, Patel JD, Vincent S, Li C, Humphries[...]

Sexually Distinct Multi-Omic Responses to Progressive Endurance Exercise Training in the Rat Lung – Findings from MoTrPAC

Many GM, Sagendorf TJ, Mitchell H, Sanford JA, Cohen S, Misra R, Estevao I, Díaz Ludovico I, Gaul DA, Lindholm ME, Ushakumary MG, Pino J,[...]

Surveying patients to assess timeliness of cancer diagnosis

O'Hanlon CE, Berdahl C, Ye F, Ohana E, Tolpadi A, Bradley MA, Marsolais E, Ptacek M, Henreid AJ, Anhang Price R. Surveying patients to assess[...]