The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

By sjmartinez • August 27, 2024

Engel JL, Zhang X, Wu M, Wang Y, Espejo Valle-Inclán J, Hu Q, Woldehawariat KS, Sanders MA, Smogorzewska A, Chen J, Cortés-Ciriano I, Lo RS, Ly P. The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance. Cell. 2024 Aug 20:S0092-8674(24)00892-4. doi: 10.1016/j.cell.2024.08.001. Epub ahead of print. PMID: 39181133.

Tags: chromothripsis, Dermatology, DNA repair, DNA replication, ecDNA, Fanconi anemia, fragile sites, genome rearrangements, genomic instability, micronuclei, mitosis, Post Doc, Publications

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