Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

By sjmartinez • June 5, 2024

Purbey PK, Seo J, Paul MK, Iwamoto KS, Daly AE, Feng AC, Champhekar AS, Langerman J, Campbell KM, Schaue D, McBride WH, Dubinett SM, Ribas A, Smale ST, Scumpia PO. Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity. Cell Rep. 2024 Jun 2;43(6):114289. doi: 10.1016/j.celrep.2024.114289. Epub ahead of print. PMID: 38833371.

Tags: antitumor immunity, Cancer, CP, cytotoxic T lymphocytes, Dermatology, Hematology/Oncology, immune checkpoint blockade, immune evasion, Immunology, interferon signaling, IRF1, PD-L1 regulation, Publications, Pulmonary, Critical Care & Sleep Medicine, scRNA-seq, TLR signaling, transcription

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