A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

By sjmartinez • May 23, 2024

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 May 20:107393. doi: 10.1016/j.jbc.2024.107393. Epub ahead of print. PMID: 38777143.

Tags: Allosteric regulation, autoimmunity, Catalysis, Cedars Sinai DoM, Intrinsically Disordered Region, Phosphoproteomics, Phosphorylation, PTPN22, Publications, Rheumatology, T‐Cell Receptor, Transcriptomics, Tyrosine Phosphatase

Related Posts

The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study

Ambatipudi M, McNeill JN, Roshandelpoor A, Alotaibi M, Mounsey LA, Hoffman E, O'Connor G, Choi SH, Allen NB, Barr RG, Jain M, Cheng S, Ho[...]

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0

Varghese C, Dachs N, Schamberg G, Abell T, Al-Haddad M, Angeli-Gordon TR, Ayazi S, Ayubi H, Bashashati M, Bulat R, Calder S, Cederwall CB, Chang[...]

Long-term outcomes of patients receiving Dialysis and undergoing Transcatheter aortic valve replacement with contemporary balloon-expandable valves

Shitan H, Patel V, Suruga K, Guo Y, Ng D, Cole B, Gupta A, Chakravarty T, Cheng W, Okada Y, Jilaihawi H, Nakamura M, Makkar[...]