A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

By sjmartinez • May 23, 2024

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 May 20:107393. doi: 10.1016/j.jbc.2024.107393. Epub ahead of print. PMID: 38777143.

Tags: Allosteric regulation, autoimmunity, Catalysis, Cedars Sinai DoM, Intrinsically Disordered Region, Phosphoproteomics, Phosphorylation, PTPN22, Publications, Rheumatology, T‐Cell Receptor, Transcriptomics, Tyrosine Phosphatase

Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021

Danpanichkul P, Duangsonk K, Tham EKJ, Tothanarungroj P, Auttapracha T, Prasitsumrit V, Sim B, Tung D, Barba R, Wong RJ, Leggio L, Yang JD, Chen[...]

A Promising Pathway Toward Mitigation and Eradication of Coronary Artery Disease

Karlsberg RP, Cho GW, Aldana-Bitar J. A Promising Pathway Toward Mitigation and Eradication of Coronary Artery Disease. Cardiol Res. 2024 Dec;15(6):415-424. doi: 10.14740/cr1721. Epub 2024[...]

2024 Update of the RECOVER-Adult Long COVID Research Index

Geng LN, Erlandson KM, Hornig M, Letts R, Selvaggi C, Ashktorab H, Atieh O, Bartram L, Brim H, Brosnahan SB, Brown J, Castro M, Charney[...]