A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

By sjmartinez • May 23, 2024

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 May 20:107393. doi: 10.1016/j.jbc.2024.107393. Epub ahead of print. PMID: 38777143.

Tags: Allosteric regulation, autoimmunity, Catalysis, Cedars Sinai DoM, Intrinsically Disordered Region, Phosphoproteomics, Phosphorylation, PTPN22, Publications, Rheumatology, T‐Cell Receptor, Transcriptomics, Tyrosine Phosphatase

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