A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling

By sjmartinez • May 23, 2024

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 May 20:107393. doi: 10.1016/j.jbc.2024.107393. Epub ahead of print. PMID: 38777143.

Tags: Allosteric regulation, autoimmunity, Catalysis, Cedars Sinai DoM, Intrinsically Disordered Region, Phosphoproteomics, Phosphorylation, PTPN22, Publications, Rheumatology, T‐Cell Receptor, Transcriptomics, Tyrosine Phosphatase

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol

MoTrPAC Study Group; Jakicic JM, Kohrt WM, Houmard JA, Miller ME, Radom-Aizik S, Rasmussen BB, Ravussin E, Serra M, Stowe CL, Trappe S, Abouassi H,[...]

Multiparametric MRI Scoring System of the Pancreas for the Diagnosis of Chronic Pancreatitis

Tirkes T, Yadav D, Conwell DL, Zhao X, Dasyam AK, Halappa VG, Patel A, Shah ZK, Swensson J, Takahashi N, Venkatesh S, Wachsman A, Li[...]

Incidence trends in upper GI cancer in young adults: a nationwide time-trend analysis using 2001-2019 United States Cancer Statistics databases

Liang J, Rastegar R, El Helou M, Mathur K, Larson BK, Waters K, Vasireddy A, Randhawa N, Mubarak M, Advani R, Osipov A, Gong J,[...]