Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity

By sjmartinez • February 26, 2024

Puumala E, Sychantha D, Lach E, Reeves S, Nabeela S, Fogal M, Nigam A, Johnson JW, Aspuru-Guzik A, Shapiro RS, Uppuluri P, Kalyaanamoorthy S, Magolan J, Whitesell L, Robbins N, Wright GD, Cowen LE. Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chem Biol. 2024 Feb 20:S2451-9456(24)00046-1. doi: 10.1016/j.chembiol.2024.01.010. Epub ahead of print. PMID: 38402621.

Tags: antifungal, Candida, fungal pathogens, Gln4, glutaminyl-tRNA synthetase, Infectious Diseases, Publications, translation inhibitor

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