Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy

By sjmartinez • February 22, 2024

Nevarez-Mejia J, Jin YP, Pickering H, Parmar R, Valenzuela NM, Sosa RA, Heidt S, Fishbein GA, Rozengurt E, Baldwin WM 3rd, Fairchild RL, Reed EF. Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy. Am J Transplant. 2023 Oct 29:S1600-6135(23)00822-5. doi: 10.1016/j.ajt.2023.10.020. Epub ahead of print. PMID: 38379280.

Tags: AMR, antibody-mediated rejection, AOIs, areas of interest, cardiac allograft vasculopathy, CAV, Digestive Diseases, donor-specific HLA antibodies, DSA, EC, endothelial cell, HLA, human leukocyte antigen, Publications, transplant vasculopathy, TV

Fibromyalgia pain may have a gut solution

Lesmana I, Qian C, Hsiao EY. Fibromyalgia pain may have a gut solution. Neuron. 2025 Jul 9;113(13):2029-2031. doi: 10.1016/j.neuron.2025.06.005. PMID: 40639338.

Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease

Alsoud D, Noor NM, Chen LA, Abadom V, Anderson SHC, Ardolli L, Axelrad J, Bossuyt P, Croitoru K, Damas OM, Deng L, Deepak P, Negro[...]

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis

Chatterjee P, Canale V, King SJ, Shawki A, Lei H, Santos AN, Haddad M, Gries C, McGovern DPB, Borneman J, McCole DF. The PTPN2 rs1893217 IBD risk[...]