In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition

By sjmartinez • February 10, 2024

Guo Q, Zhang J, Parikh K, Brinkley A, Lin S, Zakarian C, Pernet O, Shimizu S, Khamaikawin W, Hacke K, Kasahara N, An DS. In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition. Mol Ther. 2024 Feb 7;32(2):384-394. doi: 10.1016/j.ymthe.2023.12.007. Epub 2023 Dec 12. PMID: 38087779.

Tags: 6-thioguanine, C46 HIV-1 fusion inhibitor, CCR5, Hematology/Oncology, hematopoietic stem/progenitor cell based gene therapy, HIV-1, HSPC, humanized mouse, hypoxanthine-guanine phosphoribosyl transferase, in vivo selection, Publications, short hairpin RNA

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