The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

By sjmartinez • February 2, 2024

Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis. J Biol Chem. 2024 Jan 30:105702. doi: 10.1016/j.jbc.2024.105702. Epub ahead of print. PMID: 38301896.

Tags: branched-chain amino acids, BT2, cardiometabolic disease, chemical uncoupling, Endocrinology, mitochondria, Publications, ROS production

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