Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton

By sjmartinez • August 15, 2023

Benhammou JN, Qiao B, Ko A, Sinnett-Smith J, Pisegna JR, Rozengurt E. Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton. Am J Physiol Gastrointest Liver Physiol. 2023 Sep 1;325(3):G239-G250. doi: 10.1152/ajpgi.00089.2023. Epub 2023 Jun 27. PMID: 37366601.

Tags: chemoprevention, Digestive Diseases, Hepatocellular carcinoma, Publications, statin, Veterans Administration, YAP

Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in metabolic dysfunction-associated steatohepatitis models

Anand SK, Das S, Arias F, Richard KS, Rohilla S, Ghrayeb A, McKinney MP, Wang L, Tan L, Ding J, Kumar D, Pandey N, Lee[...]

Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes

Lin Q, Liu RE, Wang Q, Kang L, Chen B, Lu Y, Zhang Y, Gu Z, Zhou Y, Liu H, Xu X, Cao Z, Tang[...]

Healthy donor faecal microbiota transplantation in irritable bowel syndrome: interpreting negative findings

Liu J, Shin A. Healthy donor faecal microbiota transplantation in irritable bowel syndrome: interpreting negative findings. Lancet. 2026 Sep 24:S0140-6736(26)01815-5. doi: 10.1016/S0140-6736(26)01815-5. Epub ahead of[...]