Efficient manufacturing and engraftment of CCR5gene-edited HSPCs following busulfan conditioning in nonhuman primates

By sjmartinez • August 14, 2023

Murray J, Einhaus T, Venkataraman R, Radtke S, Zhen A, Carrillo MA, Kitchen SG, Peterson CW, Kiem HP. Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates. Mol Ther Methods Clin Dev. 2023 Jul 18;30:276-287. doi: 10.1016/j.omtm.2023.07.006. PMID: 37575091; PMCID: PMC10415663.

Tags: autologous transplant, cell therapy, conditioning, CRISPR, Gene therapy, Hematology/Oncology, hematopoietic stem cells, nonhuman primate, Publications

FURVENT: Phase 3 trial of firmonertinib vs chemotherapy as first-line treatment for advanced NSCLC with EGFR exon 20 insertion mutations (FURMO-004)

Spira A, Cho BC, Felip E, Garon EB, Goto K, Johnson M, Leighl N, Passaro A, Planchard D, Popat S, Yang JC, Lu X, Jiang[...]

Glucarpidase for Treatment of High-Dose Methotrexate Toxicity

Gupta S, Kaunfer SA, Chen KL, Dias JA, Vijayan A, Rajasekaran A, Prosek J, Truong HL, Wood A, Bassil C, Renaghan AD, Shah CV, Zhang[...]

Warm Autoimmune Hemolytic Anemia as a Rare Presentation of Pre-fibrotic Primary Myelofibrosis

Lai SY, Lo AE, Wu P. Warm Autoimmune Hemolytic Anemia as a Rare Presentation of Pre-fibrotic Primary Myelofibrosis. Cureus. 2024 Dec 5;16(12):e75155. doi: 10.7759/cureus.75155. PMID:[...]