Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition

By sjmartinez • June 12, 2023

Seaton KE, Huang Y, Karuna S, Heptinstall JR, Brackett C, Chiong K, Zhang L, Yates NL, Sampson M, Rudnicki E, Juraska M, deCamp AC, Edlefsen PT, Mullins JI, Williamson C, Rossenkhan R, Giorgi EE, Kenny A, Angier H, Randhawa A, Weiner JA, Rojas M, Sarzotti-Kelsoe M, Zhang L, Sawant S, Ackerman ME, McDermott AB, Mascola JR, Hural J, McElrath MJ, Andrew P, Hidalgo JA, Clark J, Laher F, Orrell C, Frank I, Gonzales P, Edupuganti S, Mgodi N, Corey L, Morris L, Montefiori D, Cohen MS, Gilbert PB, Tomaras GD. Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition. EBioMedicine. 2023 Jun 8;93:104590. doi: 10.1016/j.ebiom.2023.104590. Epub ahead of print. PMID: 37300931.

Tags: Body weight-based dosing, Broadly neutralising antibodies, HIV, Infectious Diseases, prevention, Publications

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