Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity

By sjmartinez • April 20, 2023

Heyden KE, Fiddler JL, Xiu Y, Malysheva OV, Handzlik MK, Phinney WN, Stiles L, Stabler SP, Metallo CM, Caudill MA, Field MS. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity. PNAS Nexus. 2023 Mar 27;2(4):pgad105. doi: 10.1093/pnasnexus/pgad105. PMID: 37077889; PMCID: PMC10109189.

Tags: DNA, Endocrinology, folate, methionine synthase, Publications, uracil, vitamin B12

Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway

Ma AM, Tran PH, Yang NL, Ngo J, Iwasaki H, Ren W, Livit S, Stiles L, Wang S, Ho T, Yim EY, Morrow N, Johnson[...]

Choice of cardioplegia influences metabolomics of human cardiac tissue

Tanosaki S, Zhang Y, Bedi K, Margulies K, Cox JE, Arany Z, Abel ED. Choice of cardioplegia influences metabolomics of human cardiac tissue. Proc Natl[...]

Editorial: Mechanisms and novel therapeutic targets and approaches for mitochondrial dysfunction in neurological and cardiovascular diseases

Li Q, Zhang Q. Editorial: Mechanisms and novel therapeutic targets and approaches for mitochondrial dysfunction in neurological and cardiovascular diseases. Front Physiol. 2026 Apr 21;17:1840059.[...]