Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer

By sjmartinez • September 19, 2022

Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L, Zhang H. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119. doi: 10.1073/pnas.2202157119. Epub 2022 Sep 19. PMID: 36122209.

Tags: AKT2, CAD, Cardiology/Epi, liver cancer, Publications, pyrimidine synthesis, β-catenin

Premature Ventricular Contractions Ablated via the Left Ventricular Annular Vein: Demonstration of 3 Possible Approaches

Kanzaki Y, Morishima I, Mori S, Shimojo K, Tanaka Y, Yamada T. Premature Ventricular Contractions Ablated via the Left Ventricular Annular Vein: Demonstration of 3[...]

Building Resilience in Academic Science and Medicine

Nguyen PK, Rodriguez-Miguelez P, Alfaidi M, Erbay E, Freed J, Hansen L, Kassiri Z, Lu HS, Oliveira SD, Wu AW, Zhang H, Chen ZB; ATVB[...]

The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study

Ambatipudi M, McNeill JN, Roshandelpoor A, Alotaibi M, Mounsey LA, Hoffman E, O'Connor G, Choi SH, Allen NB, Barr RG, Jain M, Cheng S, Ho[...]