Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer

By sjmartinez • September 19, 2022

Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L, Zhang H. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119. doi: 10.1073/pnas.2202157119. Epub 2022 Sep 19. PMID: 36122209.

Tags: AKT2, CAD, Cardiology/Epi, liver cancer, Publications, pyrimidine synthesis, β-catenin

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