Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer

By sjmartinez • September 19, 2022

Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L, Zhang H. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119. doi: 10.1073/pnas.2202157119. Epub 2022 Sep 19. PMID: 36122209.

Tags: AKT2, CAD, Cardiology/Epi, liver cancer, Publications, pyrimidine synthesis, β-catenin

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

Yao Z, Alvarez PA, Chavez C, Delgado Y, Kaushal P, Buchholz DW, Austin D, Li Q, Yu Y, Zaiss AK, Arumugaswami V, Ding Q, Hsu[...]

Isochronal Versus Electrogram-Based Conduction Velocity Estimation to Predict Inducible Monomorphic Ventricular Tachycardia in Repaired Tetralogy of Fallot

O'Leary ET, Waldmann V, Bessière F, Tan RB, Mariucci E, Chang PM, Kanter RJ, Cohen MI, Khairy P, Moore JP. Isochronal Versus Electrogram-Based Conduction Velocity[...]

Ambient fine particulate matter components and liver fat and stiffness in youth: metabolic vulnerability in PNPLA3 risk carriers

Li H, Schenker RB, Marquess KM, Paudel D, Ramirez CB, Lurmann F, Ren M, Jang C, Allayee H, Liao J, Chen Z, Goran MI, Alderete[...]