Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

By sjmartinez • August 22, 2022

Elgart M, Lyons G, Romero-Brufau S, Kurniansyah N, Brody JA, Guo X, Lin HJ, Raffield L, Gao Y, Chen H, de Vries P, Lloyd-Jones DM, Lange LA, Peloso GM, Fornage M, Rotter JI, Rich SS, Morrison AC, Psaty BM, Levy D, Redline S; NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer T. Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations. Commun Biol. 2022 Aug 22;5(1):856. doi: 10.1038/s42003-022-03812-z. PMID: 35995843; PMCID: PMC9395509.

Tags: Harbor UCLA, Med Peds, Publications

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

Ehrenberg PK, Geretz A, Volcic M, Izumi T, Yum LK, Waickman A, Shangguan S, Paquin-Proulx D, Creegan M, Bose M, Machmach K, McGraw A, Narahari[...]

Differences in fat distribution between metabolically unhealthy people with normal weight versus obesity, NHANES 2011-2018

Anand S, Pasupneti T, Pak Y, Kalangi ST, Garg R. Differences in fat distribution between metabolically unhealthy people with normal weight versus obesity, NHANES 2011-2018.[...]

Methylation risk score of C-reactive protein associates sleep health with related health outcomes

Wang Z, Wallace DA, Spitzer BW, Huang T, Taylor KD, Rotter JI, Rich SS, Liu PY, Daviglus ML, Hou L, Ramos AR, Kaur S, Durda[...]