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April 23, 2018

Ask the Doctors – Is my love of coffee genetic?

By Ask the Doctors

Dear Doctors: Everyone in my partner’s family loves coffee but I’m like the rest of my family  – we can take it or leave it. Is it possible that a love of caffeine is in their genes?

Dr. Elizabeth Ko and Dr. Eve Glazier

Dr. Elizabeth Ko and Dr. Eve Glazier

According to the National Institutes of Health, caffeine is the most widely used stimulant on earth. Found in coffee, tea, chocolate, colas, energy drinks and some medications, caffeine gives you a lift because it blocks a brain chemical called adenosine, which causes sleepiness.

Whether coffee is good or bad for you has been a source of conflicting medical opinion for quite a while. For every new study that finds the good – increased concentration, elevated mood, decreased risk of some cancers and chronic diseases, there’s another study to highlight the bad. Coffee consumption has been linked to anxiety, insomnia, high blood pressure, and an increased risk of heart attack.

Is the science on both sides of the caffeine debate wrong, or is it possible that something else is going on? In fact, scientists now believe your question hints at the answer.  Not only does your DNA decide whether or not you love coffee, the genes you carry determine how coffee will affect your body and your health.

In a study published in 2014, researchers compared coffee drinking habits among large groups of people of European and African American descent. They also did genetic studies on each group.  What they learned is that the ways in which you respond to coffee – whether it wakes you up, makes you jittery, gets you inspired or gives you the shakes – is coded into your genes. Depending on your specific genetic makeup, your body is either very, very good at processing caffeine, or isn’t efficient at all.

People in the study with the "fast" gene, which helps the liver to break down caffeine quickly, drank far more coffee than those with the "slow" gene. Researchers think that’s because caffeine leaves their bodies so quickly, it takes a lot more coffee to keep the buzz going.

When scientists separated coffee drinkers into two groups, one with the fast gene and one with the slow gene, they had an aha moment. The "fast" gene group of coffee drinkers actually showed a decreased risk of heart attack and hypertension. But people with the "slow" gene, which lets caffeine linger in the body and create more chemical interactions, had a greater rate of heart attacks and high blood pressure.

So barring a DNA test, how do you know how much coffee per day is safe to drink? Considering the many types of coffee-based drinks on the market right now, each with a different potency, it’s best to think in milligrams.

Total caffeine in a cup of coffee, for example, can range anywhere from 50 to over 400 mg. Current wisdom is up to 400 mg of caffeine per day is a safe upper limit for healthy adults. But if even a cup of weak diner coffee gets your heart racing, then decaf – or a glass of water – is the safer bet.


Eve Glazier, MD., MBA, and Elizabeth Ko, MD., are internists and assistant professors of medicine at UCLA Health.

Ask the Doctors is a syndicated column first published by UExpress syndicate.

Tags: adenosine, Ask the Doctors, Ask the Doctors, Cardiology, coffee, DNA, Dr. Eve Glazier, Dr.Elizabeth Ko, Genetics, Healthy Living, Heart Health, Research, Wellness

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